How much money do you want to spend? I think this will greatly effect what people recommend.
If you buy component speakers you can hook most the speakers directly to the head unit, but it will never sound as clear as an amp if you like to turn it up loud and you are anal about that sort of thing. A head unit that says 50watts max, is just that its MAX.. It wont be able to put out 25watts without distorting.. And if your buying speakers that are like 75watt RMS 150watt MAX 25watts isn't going to do crap.
If you want to go all out personally I would go with 3way component up front and 2way component in the back with a nice decent size 4channel amp. You shouldnt need a sub with a set of nice speakers but if you want a sub then your going to need a 5channel or use 2 amps.
http://caraudiosecurity.com/shop/product/products_id/4268.html
Something like that for the front, you can fit larger then the 6.5" in the doors but I imagine it would sound good either way. Some speaker companies you can order the individual component speakers to make a custom set with 1", 4" and 8". If you didnt know component speakers all hook into a crossover that splits the frequencys into the individual speakers, and the whole set then hooks up like one normal speaker.
Edit-
Reread your post, sounds like your keeping your 8" door subs so you would just need 2 sets of 2way components. I've used lots of headunits all brands and all the built in amps suck for nice aftermarket speakers like I was saying before, but of all I have used my midpriced Alpine (400$) sounded the best when turned up. But I would still get a real amp for your main speakers if you are willing to spend the money.